Hi!
No daft questions here! Or maybe they're just all daft questions, how would we know the difference?
I think it would be arguably easier to adapt Microlite to remove magic, at least compared to a number of other d20-based games (including the Usual Suspects). The basic magic system in m20 (powered by HP) means that magic-users already start with a similar level of endurance as other classes.
The only thing you might want to keep an eye on is damage output of non-magic wielders versus the HP of enemies, especially at higher levels. I recently ran an m20-based campaign where there was no "magic" as such, although the party did have a chemist that could do some magic-esque things. There were also options for the "fighter" do up damage using something like martial feats, and as a result I found I had to toughen the enemies up quite a bit to challenge them. But if you're planning on sticking close to Purest Essence I could see it going the other way as well. If you have nothing but "vanilla" fighters doing 1d6-1d10 tops each round, make sure your enemies don't have hundreds of HP they'll need to hack through.
Otherwise m20 should give you a great chassis for a magic-free game, IMO.